We identify an unexpected function of PODXL as a decoy receptor for galectin-3 (GA元), whereby the PODXL-GA元 interaction releases GA元 repression of integrin-based invasion. How PODXL presents this duality in effect remains unknown. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types.
The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Bryant +24 authors +22 authors +17 authors fewer Authors Info & Affiliations Norman, Sara Zanivan, Karen Blyth, and David M. Cumming, , Ji Park, Konstantina Nikolatou, Sergio Lilla, Robin Shaw, David Strachan, Susan Mason, Rachana Patel, Lynn McGarry, Archana Katoch, Kirsteen J.
Kugeratski, Jayanthi Anand, , Emma Sandilands, Laura Galbraith, Kai Rakovic, Eva C.
0 kommentar(er)
